[Blueboard] Seminar Invitation on Fruit flies as models in animal development

Gina B. Mamauag gmamauag at ateneo.edu
Mon Nov 16 11:31:02 PHT 2015

The Chemistry Department and SOSE invite you to the following seminar:

*Tools and Insights:*

*Drosophila (fruit flies) at the Centre of Signaling*

Franz Wendler, Ph.D.

Thursday, 26 November 2015

4:30-6:00 pm

Schmitt Hall Room 109


Traditionally, the fruit fly *Drosophila melanogaster* entered the
main-stream of developmental biology at the beginning of the 20th century
and serves ever since as one of the most prevalent model organisms to study
cell-fate determination, tissue specification and maintenances during
development and in adulthood. This finds justification due to the high
evolutionary  conservation of signaling pathways that determine these
processes. In order to advance our understandings an ever increasing
toolbox and fly-strain repositories have been created including transgenic
strains that allow clonal analysis after allele switching or the knockdown
of any protein in question in any target tissue during certain
developmental stages. Moreover, protocols have been developed to generate
and express any desirable gene mutation in a tissue- or even cell
type-specific manner or to perform whole genomic functional surveys to find
new players in the respective pathways.

Here, I will focus on some of the methods that led to new insights into the
wing development and revealed fundamental evolutionary principles. These
concerns two major signaling pathways, the Wingless (Wg, Wnt) and the
Hedgehog (Hh) pathways. Both pathways have in common that a receptor
ligand, Wg and Hh, respectively, is produced in a localized set of cells
from where they are secreted and released thereby forming a concentration
gradient throughout a receptive tissue. Accordingly, their local strength
determines gene expression pattern and therefore cell identity. Both
pathways are integral part during human development and tissue homeostasis
as misregulation can lead to different forms of brain, lung, liver and
other forms of cancer and metabolic deseases.

*About the speaker:*

Franz Wendler received his Ph.D. at the Karl Franzens University in Graz,
Austria, where he worked on multi-drug resistance in yeast. He worked at
Cancer Research UK (former ICRF), the National Institute of Medical
Research, UK, IBV Nice, France, University of Massachusetts Medical School
and Harvard Medical School in the US, and also trained at University of
Utrecht, Netherlands, and University of Zurich, Switzerland.

*Gina Mamauag-Buan*

*Chemistry Department*
*Ateneo de Manila University*
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