[Blueboard] Lecture on Modelling Dopamine Synthesis

Editha V. Bagtas ebagtas at ateneo.edu
Tue Sep 10 14:03:49 PHT 2013


The Ateneo de Manila University
Mathematics Department

cordially invites you to a talk on


A Mathematical Model of Dopamine Synthesis
in Renal Proximal Tubule Cells

by



Patrick Vincent N. Lubenia, MS
Mathematics Department
School of Science and Engineering


on Monday, September 16, 2013
4:30 - 5:30 pm at SECA 303.


Abstract

One of the causes of hypertension is too much salt in the blood. This
may be brought about by abnormalities in dopamine production and
reception in renal proximal tubule (RPT) cells which are located in
the kidneys. Not much literature is available regarding human renal
dopamine, but much has been established regarding the production and
reception of dopamine in the human brain. Some of the key players in
the metabolism of dopamine in the brain are also present in the RPT
cells. The processes surrounding dopamine synthesis and reception in
the kidneys are explored by constructing a renal dopamine model which
initially assumes that the same dynamics in the brain also happens in
the kidneys. The Generalized Mass Action (GMA) formalism, a variant of
Biochemical Systems Theory (BST), is used in setting up the system of
ordinary differential equations. Computer simulations show that the
results for dopamine metabolism in the brain are much different when
used in the renal dopamine model. The initial model is modified in
order to reflect expert opinion.


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