[Blueboard] Seminar on Ion channels

Dr. Fabian M. Dayrit fdayrit at ateneo.edu
Wed Jun 22 10:15:54 PHT 2011

Please post.

You are cordially invited to the seminar:

Ion Selectivity of Engineered alpha-Hemolysin Channels and the KcsA
Potassium Channel

To be fiven by: Bernhard Egwolf, Dr. rer. nat.

Date / Time: June 24, 2011 (Friday) / 4:30pm
Place: Schmitt Hall, C109


The alpha-hemolysin and the KcsA potassium channels are proteins
forming pores in biological membranes. The alpha-hemolysin channel
has a wide pore diameter and it is slightly anion selective, that is,
more negative than positive ions pass through it. It can be engineered
for biotechnological applications by attaching a molecular adapter like
beta-cyclodextrin, which is an electrically neutral molecule. Nevertheless,
it is able to increase the anion selectivity of alpha-hemolysin. How this
works was studied with the grand canonical Monte Carlo/Brownian dynamics
algorithm, which is able to simulate ion fluxes through wide pores.
The KcsA potassium channel has a very narrow part, which is called
selectivity filter. This part of the pore is very selective for potassium over
other cations like sodium. In order to study what happens to a potassium
and a sodium ion entering the selectivity filter, the corresponding free
energy landscapes were calculated using umbrella sampling molecular
dynamics simulations.  

About the presentor:

Dr. Bernhard Egwolf received his Doctor of Natural Sciences degree in
Physics (magna cum laude) from the Ludwig Maximilian University of
Munich, Germany, in 2004. He worked as a postdoctoral researcher with
Benoit Roux at the University of Chicago in 2005, and then with Helmut
Grubmueller at the Max Planck Institute for Biophysical Chemistry,
Goettingen, Germany, from 2009 to 2011.

His research interests include Theoretical and Computational
Biophysics and Molecular Biology and Molecular Dynamics.

Dr. Fabian M. Dayrit
Dean, School of Science & Engineering
Professor, Department of Chemistry
Ateneo de Manila University
Loyola Heights
1108 Quezon City, Philippines

Mailing address:
P.O. Box 154, Manila Central Post Office
0917 Manila, Philippines

Tel: (632) 426-6001 ext 5600
Fax: (632) 426-5985
Email: fdayrit at ateneo.edu

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