[Blueboard] Biology Lecture Series 3

BIOLOGY DEPARTMENT biology at admu.edu.ph
Mon Sep 3 00:39:08 PHT 2001


EVERBODY IS INVITED

Date: September 7, 2001
Venue: SEC Lecture Hall 2
Time: 4:30 pm

BIOTECHNOLOGY AND BLOOD TRANSFUSION

Romulo de Villa, MD, PhD, Cert. Biochemistry

Biotechnology is a production technique that utilizes living organisms or
functional proteins derived from living organisms in order to manufacture
products.
Classical Biotechnology of fermentation is used in the production of beer,
bagoong and other products. Modern biotechnology utilizes Molecular Biology
techniques to produce novel products, not otherwise produced by the living
organism. The use of Molecular Biology techniques on various aspects of
transfusion medicine has led to significant improvement in the areas of
diagnosis, therapy and production of human blood products.

In the field of diagnostic testing, the screening for the presence of
viruses in blood that will be transfused has been expanded with the
development of multiplex PCR and DNA array screening. Antigen detection of
red cell groups, platelets and granulocytes can now be done by Polymerase
Chain Reaction and subsequently Allele Specific Restriction enzyme
Analysis (PCR-ASRA), Restriction Fragment Length Polymorphism (RFLP),
Sequence Specific Primer- Polymerase Chain Reaction (SSP- PCR) and blot
hybridization techniques.

These developments were brought about by the characterization of the genes
that code for the red cell group antigens, platelet and granulocyte
antigens. ABO blood group determination will not be required with the
technology of converting type A or type B red cells into type O blood
using biological enzymes. In the field of therapeutics, defects of
hematopoietic stem cells can be corrected with gene therapy and blood
products such as Granulocyte- Colony Stimulating Factor (G-CSF),
Granulocyte/Macrophage- CSF (GM-CSF), erythropoietin and blood clotting
factors can be produced in cell cultures and transgenic whole animals.


For more information:
Contact the Biology Department
c/o    Tessie at 5610 or
email: biology at admu.edu.ph







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